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Conformationally restricted calpain inhibitors
The cysteine protease calpain-I is linked to several diseases and is therefore a valuable target for inhibition. Selective inhibition of calpain-I has proved difficult as most compounds target the active site and inhibit a broad spectrum of cysteine proteases as well as other calpain isoforms. Selec...
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| Vydáno v: | Chem Sci |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Royal Society of Chemistry
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508670/ https://ncbi.nlm.nih.gov/pubmed/28757975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01158b |
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