Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities

Atropisomeric drug substances are known to have different biological properties. Compounds containing the N-benzoylbenzazepine motif have been shown to exhibit energetically restricted rotation around the Ar(CO)N axis. Herein we report, for the first time, the synthesis, physical characterisation an...

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Vydáno v:Medchemcomm
Hlavní autoři: Fordyce, Euan A. F., Fraser Hunt, S., Crepin, Damien, Onions, Stuart T., Parra, Guillaume F., Sleigh, Chris J., King-Underwood, John, Finch, Harry, Murray, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072213/
https://ncbi.nlm.nih.gov/pubmed/30108949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00033f
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