Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation

Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a C. elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation...

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Publicado en:Dev Cell
Autores principales: Liu, Huayang, Dowdle, James A., Khurshid, Safiya, Sullivan, Nicholas J., Bertos, Nicholas, Rambani, Komal, Mair, Markus, Daniel, Piotr, Wheeler, Esther, Tang, Xing, Toth, Kyle, Lause, Michael, Harrigan, Markus E., Eiring, Karl, Sullivan, Connor, Sullivan, Matthew J., Chang, Serena W., Srivastava, Siddhant, Conway, Joseph S., Kladney, Raleigh, McElroy, Joseph, Bae, Sooin, Lu, Yuanzhi, Tofigh, Ali, Saleh, Sadiq M. I., Fernandez, Soledad A., Parvin, Jeffrey D., Coppola, Vincenzo, Macrae, Erin R., Majumder, Sarmila, Shapiro, Charles L., Yee, Lisa D., Ramaswamy, Bhuvaneswari, Hallett, Michael, Ostrowski, Michael C., Park, Morag, Chamberlin, Helen M., Leone, Gustavo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508591/
https://ncbi.nlm.nih.gov/pubmed/28535374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.024
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