Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation

Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a C. elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation...

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Veröffentlicht in:Dev Cell
Hauptverfasser: Liu, Huayang, Dowdle, James A., Khurshid, Safiya, Sullivan, Nicholas J., Bertos, Nicholas, Rambani, Komal, Mair, Markus, Daniel, Piotr, Wheeler, Esther, Tang, Xing, Toth, Kyle, Lause, Michael, Harrigan, Markus E., Eiring, Karl, Sullivan, Connor, Sullivan, Matthew J., Chang, Serena W., Srivastava, Siddhant, Conway, Joseph S., Kladney, Raleigh, McElroy, Joseph, Bae, Sooin, Lu, Yuanzhi, Tofigh, Ali, Saleh, Sadiq M. I., Fernandez, Soledad A., Parvin, Jeffrey D., Coppola, Vincenzo, Macrae, Erin R., Majumder, Sarmila, Shapiro, Charles L., Yee, Lisa D., Ramaswamy, Bhuvaneswari, Hallett, Michael, Ostrowski, Michael C., Park, Morag, Chamberlin, Helen M., Leone, Gustavo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508591/
https://ncbi.nlm.nih.gov/pubmed/28535374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.024
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