Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation

Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a C. elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Cell
Prif Awduron: Liu, Huayang, Dowdle, James A., Khurshid, Safiya, Sullivan, Nicholas J., Bertos, Nicholas, Rambani, Komal, Mair, Markus, Daniel, Piotr, Wheeler, Esther, Tang, Xing, Toth, Kyle, Lause, Michael, Harrigan, Markus E., Eiring, Karl, Sullivan, Connor, Sullivan, Matthew J., Chang, Serena W., Srivastava, Siddhant, Conway, Joseph S., Kladney, Raleigh, McElroy, Joseph, Bae, Sooin, Lu, Yuanzhi, Tofigh, Ali, Saleh, Sadiq M. I., Fernandez, Soledad A., Parvin, Jeffrey D., Coppola, Vincenzo, Macrae, Erin R., Majumder, Sarmila, Shapiro, Charles L., Yee, Lisa D., Ramaswamy, Bhuvaneswari, Hallett, Michael, Ostrowski, Michael C., Park, Morag, Chamberlin, Helen M., Leone, Gustavo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508591/
https://ncbi.nlm.nih.gov/pubmed/28535374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.024
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