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Continued optimization of the M(5) NAM ML375: Discovery of VU6008667, an M(5) NAM with high CNS penetration and a desired short half-life in rat for addiction studies
This letter describes the continued optimization of M(5) NAM ML375 (VU0483253). While a valuable in vivo tool compound, ML375 has an excessively long elimination half-life in rat (t(1/2) = 80 hours), which can be problematic in certain rodent addiction paradigms (e.g., reinstatement). Thus, we requi...
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| Publicado no: | Bioorg Med Chem Lett |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508536/ https://ncbi.nlm.nih.gov/pubmed/28237763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.02.020 |
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