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Tissue plasminogen activator mediates deleterious complement cascade activation in stroke

The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood. The purpose of this study was to delineate a...

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Publicado en:PLoS One
Autores principales: Zhao, Xue-Jun, Larkin, Timothy M., Lauver, Molly A., Ahmad, Saif, Ducruet, Andrew F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507253/
https://ncbi.nlm.nih.gov/pubmed/28700732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180822
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