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Tissue plasminogen activator mediates deleterious complement cascade activation in stroke

The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood. The purpose of this study was to delineate a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhao, Xue-Jun, Larkin, Timothy M., Lauver, Molly A., Ahmad, Saif, Ducruet, Andrew F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507253/
https://ncbi.nlm.nih.gov/pubmed/28700732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180822
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