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Protein sites with more coevolutionary connections tend to evolve slower, while more variable protein families acquire higher coevolutionary connections

Background: Amino acid exchanges within proteins sometimes compensate for one another and could therefore be co-evolved. It is essential to investigate the intricate relationship between the extent of coevolution and the evolutionary variability exerted at individual protein sites, as well as the wh...

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Pubblicato in:F1000Res
Autori principali: Mandloi, Sapan, Chakrabarti, Saikat
Natura: Artigo
Lingua:Inglês
Pubblicazione: F1000Research 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506539/
https://ncbi.nlm.nih.gov/pubmed/28751967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.11251.2
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