Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan

Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non‐neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO (+/−))...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Aging Cell
Päätekijät: Merry, Troy L., Kuhlow, Doreen, Laube, Beate, Pöhlmann, Doris, Pfeiffer, Andreas F. H., Kahn, C. Ronald, Ristow, Michael, Zarse, Kim
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2017
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506415/
https://ncbi.nlm.nih.gov/pubmed/28544360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12610
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia