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Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non‐neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO (+/−))...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5506415/ https://ncbi.nlm.nih.gov/pubmed/28544360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12610 |
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