Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

Excessive insulin signaling through the insulin receptor (IR) may play a role in the pathogenesis of diet-induced metabolic disease, including obesity and type 2 diabetes. Here we investigate whether heterozygous impairment of insulin receptor (IR) expression limited to peripheral, i.e. non-CNS, tis...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Merry, Troy L., Hedges, Chris P., Masson, Stewart W., Laube, Beate, Pöhlmann, Doris, Wueest, Stephan, Walsh, Michael E., Arnold, Myrtha, Langhans, Wolfgang, Konrad, Daniel, Zarse, Kim, Ristow, Michael
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190665/
https://ncbi.nlm.nih.gov/pubmed/32350271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15623-z
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