Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan

Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non‐neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO (+/−))...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Merry, Troy L., Kuhlow, Doreen, Laube, Beate, Pöhlmann, Doris, Pfeiffer, Andreas F. H., Kahn, C. Ronald, Ristow, Michael, Zarse, Kim
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506415/
https://ncbi.nlm.nih.gov/pubmed/28544360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12610
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