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Biomarkers allow detection of nutrient limitations and respective supplementation for elimination in Pichia pastoris fed-batch cultures

BACKGROUND: Industrial processes for recombinant protein production challenge production hosts, such as the yeast Pichia pastoris, on multiple levels. During a common P. pastoris fed-batch process, cells experience strong adaptations to different metabolic states or suffer from environmental stresse...

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Publicat a:Microb Cell Fact
Autors principals: Burgard, Jonas, Valli, Minoska, Graf, Alexandra B., Gasser, Brigitte, Mattanovich, Diethard
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504661/
https://ncbi.nlm.nih.gov/pubmed/28693509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-017-0730-9
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