Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma

Here, we examined the potential of blocking the thymidine de novo synthesis pathways for sensitizing melanoma cells to the nucleoside salvage pathway targeting endogenous DNA irradiation. Expression of key nucleotide synthesis and proliferation enzymes thymidylate synthase (TS) and thymidine kinase...

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Bibliografiske detaljer
Udgivet i:Cancer Med
Main Authors: Miran, Tara, Vogg, Andreas T. J., El Moussaoui, Laila, Kaiser, Hans‐Jürgen, Drude, Natascha, von Felbert, Verena, Mottaghy, Felix M., Morgenroth, Agnieszka
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Clinical Cancer Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504322/
https://ncbi.nlm.nih.gov/pubmed/28608446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1113
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