Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma

Here, we examined the potential of blocking the thymidine de novo synthesis pathways for sensitizing melanoma cells to the nucleoside salvage pathway targeting endogenous DNA irradiation. Expression of key nucleotide synthesis and proliferation enzymes thymidylate synthase (TS) and thymidine kinase...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Miran, Tara, Vogg, Andreas T. J., El Moussaoui, Laila, Kaiser, Hans‐Jürgen, Drude, Natascha, von Felbert, Verena, Mottaghy, Felix M., Morgenroth, Agnieszka
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Clinical Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504322/
https://ncbi.nlm.nih.gov/pubmed/28608446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1113
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