Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma

Here, we examined the potential of blocking the thymidine de novo synthesis pathways for sensitizing melanoma cells to the nucleoside salvage pathway targeting endogenous DNA irradiation. Expression of key nucleotide synthesis and proliferation enzymes thymidylate synthase (TS) and thymidine kinase...

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Dades bibliogràfiques
Publicat a:Cancer Med
Autors principals: Miran, Tara, Vogg, Andreas T. J., El Moussaoui, Laila, Kaiser, Hans‐Jürgen, Drude, Natascha, von Felbert, Verena, Mottaghy, Felix M., Morgenroth, Agnieszka
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Clinical Cancer Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504322/
https://ncbi.nlm.nih.gov/pubmed/28608446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1113
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