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Potentiation of receptor responses induced by prolonged binding of Gα(13) and leukemia-associated RhoGEF

Diverse cellular functions are controlled by RhoA-GTPases, which are activated by trimeric G proteins via RhoGEFs, among others. In this study, we focused on the signaling from GPCRs to RhoA via Gα(13) and leukemia-associated RhoGEF (LARG). The activation of Gα(13) was elucidated in living cells wit...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Bodmann, Eva-Lisa, Krett, Anna-Lena, Bünemann, Moritz
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503709/
https://ncbi.nlm.nih.gov/pubmed/28465324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700026R
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