Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development

Low nephron endowment at birth has been associated with an increased risk for developing hypertension and chronic kidney disease. We demonstrated in an earlier study that conditional deletion of the microRNA (miRNA)-processing enzyme Dicer from nephron progenitors results in premature depletion of t...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Cerqueira, Débora M., Bodnar, Andrew J., Phua, Yu Leng, Freer, Rachel, Hemker, Shelby L., Walensky, Loren D., Hukriede, Neil A., Ho, Jacqueline
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503708/
https://ncbi.nlm.nih.gov/pubmed/28446592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700010R
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