Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation

BACKGROUND: Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that cont...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Cargill, Kasey, Hemker, Shelby L., Clugston, Andrew, Murali, Anjana, Mukherjee, Elina, Liu, Jiao, Bushnell, Daniel, Bodnar, Andrew J., Saifudeen, Zubaida, Ho, Jacqueline, Bates, Carlton M., Kostka, Dennis, Goetzman, Eric S., Sims-Lucas, Sunder
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2019
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622426/
https://ncbi.nlm.nih.gov/pubmed/31142573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018111170
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