Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/β-catenin signaling and is frequently methylated in breast cancer

Dickkopf-related protein 2 (DKK2) is one of the antagonists of Wnt/β-catenin signaling, with its downregulation reported in multiple cancers. However, how DKK2 contributes to breast tumorigenesis remains unclear. We examined its expression and promoter methylation in 10 breast tumor cell lines, 98 p...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Mu, Junhao, Hui, Tianli, Shao, Bianfei, Li, Lili, Du, Zhenfang, Lu, Li, Ye, Lin, Li, Shuman, Li, Qianqian, Xiao, Qian, Qiu, Zhu, Zhang, Yan, Fan, Jiangxia, Ren, Guosheng, Tao, Qian, Xiang, Tingxiu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503624/
https://ncbi.nlm.nih.gov/pubmed/28467796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17055
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