Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells

Dickkopf-related protein 3 (DKK3) is an antagonist of Wnt ligand activity. Reduced DKK3 expression has been reported in various types of cancers, but its functions and related molecular mechanisms in breast tumorigenesis remain unclear. We examined the expression and promoter methylation of DKK3 in...

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Bibliografske podrobnosti
Main Authors: Xiang, Tingxiu, Li, Lili, Yin, Xuedong, Zhong, Lan, Peng, Weiyan, Qiu, Zhu, Ren, Guosheng, Tao, Qian
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2013
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159020/
https://ncbi.nlm.nih.gov/pubmed/23890219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12099
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