Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/β-catenin signaling and is frequently methylated in breast cancer

Dickkopf-related protein 2 (DKK2) is one of the antagonists of Wnt/β-catenin signaling, with its downregulation reported in multiple cancers. However, how DKK2 contributes to breast tumorigenesis remains unclear. We examined its expression and promoter methylation in 10 breast tumor cell lines, 98 p...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mu, Junhao, Hui, Tianli, Shao, Bianfei, Li, Lili, Du, Zhenfang, Lu, Li, Ye, Lin, Li, Shuman, Li, Qianqian, Xiao, Qian, Qiu, Zhu, Zhang, Yan, Fan, Jiangxia, Ren, Guosheng, Tao, Qian, Xiang, Tingxiu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503624/
https://ncbi.nlm.nih.gov/pubmed/28467796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17055
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