The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

Adenylyl cyclases (ACs) generate cAMP, a second messenger of utmost importance that regulates a vast array of biological processes in all kingdoms of life. However, almost nothing is known about how AC activity is regulated through protein degradation mediated by ubiquitination or other mechanisms....

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hu, Wenbao, Yu, Xiaojie, Liu, Zhengzhao, Sun, Ying, Chen, Xibing, Yang, Xin, Li, Xiaofen, Lam, Wai Kwan, Duan, Yuanyuan, Cao, Xu, Steller, Hermann, Liu, Kai, Huang, Pingbo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503512/
https://ncbi.nlm.nih.gov/pubmed/28656888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28021
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