Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies

The present work describes the synthesis of few hydroxylated amide derivatives as melanogenesis inhibitors. In vitro, in vivo and computational studies proved that compound 6d is a highly potent melanogenesis inhibitor compared to standard kojic acid. The title amides 4a–e and 6a–e were synthesized...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Abbas, Qamar, Ashraf, Zaman, Hassan, Mubashir, Nadeem, Humaira, Latif, Muhammad, Afzal, Samina, Seo, Sung-Yum
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503496/
https://ncbi.nlm.nih.gov/pubmed/28740364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S137550
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