Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning

Nucleosomes play important structural and regulatory roles by tightly wrapping the DNA that constitutes the metazoan genome. The Polycomb group (PcG) proteins modulate nucleosomes to maintain repression of key developmental genes, including Hox genes whose temporal and spatial expression is tightly...

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Publicat a:Science
Autors principals: Lau, Mei Sheng, Schwartz, Matthew G., Kundu, Sharmistha, Savol, Andrej J., Wang, Peggy I., Marr, Sharon K., Grau, Daniel J., Schorderet, Patrick, Sadreyev, Ruslan I., Tabin, Clifford J., Kingston, Robert E.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503153/
https://ncbi.nlm.nih.gov/pubmed/28280206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah5403
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