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Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning
Nucleosomes play important structural and regulatory roles by tightly wrapping the DNA that constitutes the metazoan genome. The Polycomb group (PcG) proteins modulate nucleosomes to maintain repression of key developmental genes, including Hox genes whose temporal and spatial expression is tightly...
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| Опубликовано в: : | Science |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503153/ https://ncbi.nlm.nih.gov/pubmed/28280206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah5403 |
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