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Chiral Brønsted Acid‐Catalyzed Asymmetric Synthesis of N‐Aryl‐cis‐aziridine Carboxylate Esters

We report a multi‐component asymmetric Brønsted acid‐catalyzed aza‐Darzens reaction which is not limited to specific aromatic or heterocyclic aldehydes. Incorporating alkyl diazoacetates and, important for high ee's, ortho‐tert‐butoxyaniline our optimized reaction (i.e. solvent, temperature and...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Bew, Sean P., Liddle, John, Hughes, David L., Pesce, Paolo, Thurston, Sean M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502890/
https://ncbi.nlm.nih.gov/pubmed/28378388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201611990
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