The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model

Activating germline mutations of anaplastic lymphoma kinase (ALK) occur in most cases of hereditary neuroblastoma (NB) and the constitutively active kinase activity of ALK promotes cell proliferation and survival in NB. Therefore, ALK kinase is a potential therapeutic target for NB. In this study, w...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cancer Lett
Huvudupphovsmän: Lu, Jiaxiong, Guan, Shan, Zhao, Yanlin, Yu, Yang, Woodfield, Sarah E., Zhang, Huiyuan, Yang, Kristine L., Bieerkehazhi, Shayahati, Qi, Lin, Li, Xiaonan, Gu, Jerry, Xu, Xin, Jin, Jinling, Muscal, Jodi A., Yang, Tianshu, Xu, Guo-Tong, Yang, Jianhua
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502736/
https://ncbi.nlm.nih.gov/pubmed/28455243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.04.022
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk