The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model

Activating germline mutations of anaplastic lymphoma kinase (ALK) occur in most cases of hereditary neuroblastoma (NB) and the constitutively active kinase activity of ALK promotes cell proliferation and survival in NB. Therefore, ALK kinase is a potential therapeutic target for NB. In this study, w...

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Publicado no:Cancer Lett
Main Authors: Lu, Jiaxiong, Guan, Shan, Zhao, Yanlin, Yu, Yang, Woodfield, Sarah E., Zhang, Huiyuan, Yang, Kristine L., Bieerkehazhi, Shayahati, Qi, Lin, Li, Xiaonan, Gu, Jerry, Xu, Xin, Jin, Jinling, Muscal, Jodi A., Yang, Tianshu, Xu, Guo-Tong, Yang, Jianhua
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502736/
https://ncbi.nlm.nih.gov/pubmed/28455243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.04.022
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