Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a pepti...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Ciolek, Justyna, Reinfrank, Helen, Quinton, Loïc, Viengchareun, Say, Stura, Enrico A., Vera, Laura, Sigismeau, Sabrina, Mouillac, Bernard, Orcel, Hélène, Peigneur, Steve, Tytgat, Jan, Droctové, Laura, Beau, Fabrice, Nevoux, Jerome, Lombès, Marc, Mourier, Gilles, De Pauw, Edwin, Servent, Denis, Mendre, Christiane, Witzgall, Ralph, Gilles, Nicolas
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502595/
https://ncbi.nlm.nih.gov/pubmed/28630289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620454114
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