Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates

Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the Na(V)1.7 subtype of voltage-gated sodium (Na(V)) c...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Gonçalves, Tânia C., Lesport, Pierre, Kuylle, Sarah, Stura, Enrico, Ciolek, Justyna, Mourier, Gilles, Servent, Denis, Bourinet, Emmanuel, Benoit, Evelyne, Gilles, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784069/
https://ncbi.nlm.nih.gov/pubmed/31443554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11090484
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