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Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates

Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the Na(V)1.7 subtype of voltage-gated sodium (Na(V)) c...

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Dades bibliogràfiques
Publicat a:Toxins (Basel)
Autors principals: Gonçalves, Tânia C., Lesport, Pierre, Kuylle, Sarah, Stura, Enrico, Ciolek, Justyna, Mourier, Gilles, Servent, Denis, Bourinet, Emmanuel, Benoit, Evelyne, Gilles, Nicolas
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784069/
https://ncbi.nlm.nih.gov/pubmed/31443554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11090484
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