Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates

Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the Na(V)1.7 subtype of voltage-gated sodium (Na(V)) c...

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Bibliographic Details
Published in:Toxins (Basel)
Main Authors: Gonçalves, Tânia C., Lesport, Pierre, Kuylle, Sarah, Stura, Enrico, Ciolek, Justyna, Mourier, Gilles, Servent, Denis, Bourinet, Emmanuel, Benoit, Evelyne, Gilles, Nicolas
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784069/
https://ncbi.nlm.nih.gov/pubmed/31443554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11090484
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