Cytotoxic T cell functions accumulate when CD4 is downregulated by CD4(+) T cells in African green monkeys()

African green monkeys (AGMs) are a natural host of simian immunodeficiency virus (SIVagm) that do not develop simian AIDS. Adult AGMs naturally have low numbers of CD4(+) T cells and a large population of MHC Class II-restricted CD8αα T cells that are generated through CD4 down-regulation in CD4(+)...

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Veröffentlicht in:J Immunol
Hauptverfasser: Vinton, Carol L., Ortiz, Alexandra M., Calantone, Nina, Mudd, Joseph C., Deleage, Claire, Morcock, David R., Whitted, Sonya, Estes, Jacob D., Hirsch, Vanessa M., Brenchley, Jason M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502537/
https://ncbi.nlm.nih.gov/pubmed/28438898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700136
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