Homeostatic Cytokines Induce CD4 Downregulation in African Green Monkeys Independently of Antigen Exposure To Generate Simian Immunodeficiency Virus-Resistant CD8αα T Cells

African green monkeys (AGMs; genus Chlorocebus) are a natural host of simian immunodeficiency virus (SIV(AGM)). As they do not develop simian AIDS, there is great interest in understanding how this species has evolved to avoid immunodeficiency. Adult African green monkeys naturally have low numbers...

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Autors principals: Perkins, Molly R., Briant, Judith A., Calantone, Nina, Whitted, Sonya, Vinton, Carol L., Klatt, Nichole R., Ourmanov, Ilnour, Ortiz, Alexandra M., Hirsch, Vanessa M., Brenchley, Jason M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178902/
https://ncbi.nlm.nih.gov/pubmed/24991011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01331-14
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