Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription

DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation we quantified allelic variability in...

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Veröffentlicht in:Science
Hauptverfasser: Kilpinen, Helena, Waszak, Sebastian M, Gschwind, Andreas R, Raghav, Sunil K, Witwicki, Robert M, Orioli, Andrea, Migliavacca, Eugenia, Wiederkehr, Michaël, Gutierrez-Arcelus, Maria, Panousis, Nikolaos, Yurovsky, Alisa, Lappalainen, Tuuli, Romano-Palumbo, Luciana, Planchon, Alexandra, Bielser, Deborah, Bryois, Julien, Padioleau, Ismael, Udin, Gilles, Thurnheer, Sarah, Hacker, David, Core, Leighton J, Lis, John T, Hernandez, Nouria, Reymond, Alexandre, Deplancke, Bart, Dermitzakis, Emmanouil T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502466/
https://ncbi.nlm.nih.gov/pubmed/24136355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1242463
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