Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription

DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation we quantified allelic variability in...

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Pubblicato in:Science
Autori principali: Kilpinen, Helena, Waszak, Sebastian M, Gschwind, Andreas R, Raghav, Sunil K, Witwicki, Robert M, Orioli, Andrea, Migliavacca, Eugenia, Wiederkehr, Michaël, Gutierrez-Arcelus, Maria, Panousis, Nikolaos, Yurovsky, Alisa, Lappalainen, Tuuli, Romano-Palumbo, Luciana, Planchon, Alexandra, Bielser, Deborah, Bryois, Julien, Padioleau, Ismael, Udin, Gilles, Thurnheer, Sarah, Hacker, David, Core, Leighton J, Lis, John T, Hernandez, Nouria, Reymond, Alexandre, Deplancke, Bart, Dermitzakis, Emmanouil T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502466/
https://ncbi.nlm.nih.gov/pubmed/24136355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1242463
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