IDENTIFICATION A DNA DAMAGE-INDUCED ALTERNATIVE SPLICING PATHWAY THAT REGULATES p53 AND CELLULAR SENESCENCE MARKERS

Cellular responses to DNA damage are critical determinants of cancer development and aging-associated pathogenesis. Here we report a novel DNA damage response pathway that regulates alternative splicing of numerous gene products, including the human tumor suppressor p53, and controls DNA damage-indu...

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Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Chen, Jing, Crutchley, John, Zhang, Dadong, Owzar, Kouros, Kastan, Michael B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501752/
https://ncbi.nlm.nih.gov/pubmed/28288992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0908
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