A FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice

Tissue homeostasis requires production of newly differentiated cells from resident adult stem cells. Central to this process is the expansion of undifferentiated intermediates known as transit-amplifying (TA) cells, but how stem cells are triggered to enter this proliferative TA state remains an imp...

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Udgivet i:Cell Stem Cell
Main Authors: Hu, Jimmy Kuang-Hsien, Du, Wei, Shelton, Samuel J., Oldham, Michael C., DiPersio, C. Michael, Klein, Ophir D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501749/
https://ncbi.nlm.nih.gov/pubmed/28457749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.03.023
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