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YAP enters the mTOR pathway to promote tuberous sclerosis complex
Mutations in tuberous sclerosis complex 1 (TSC1) or TSC2 predispose to angiomyolipomas and lymphangioleiomyomatosis in a mTOR-dependent manner. In these mesenchymal lesions, mTOR suppresses macroautophagy-mediated lysosomal degradation of YAP, which is a transcriptional coactivator of Hippo pathway...
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| Published in: | Mol Cell Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905364/ https://ncbi.nlm.nih.gov/pubmed/27308518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2014.998100 |
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