Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

Genetic studies have shown that the tuberous sclerosis complex (TSC) 1–TSC2–mammalian target of Rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are master regulators of organ size, which are often involved in tumorigenesis. The crosstalk between these signal transduction pathw...

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Main Authors: Liang, Ning, Zhang, Chi, Dill, Patricia, Panasyuk, Ganna, Pion, Delphine, Koka, Vonda, Gallazzini, Morgan, Olson, Eric N., Lam, Hilaire, Henske, Elizabeth P., Dong, Zheng, Apte, Udayan, Pallet, Nicolas, Johnson, Randy L., Terzi, Fabiola, Kwiatkowski, David J., Scoazec, Jean-Yves, Martignoni, Guido, Pende, Mario
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203941/
https://ncbi.nlm.nih.gov/pubmed/25288394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140341
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