NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma

Inflammasomes are mediators of inflammation, and constitutively activated NLRP3 inflammasomes have been linked to IL-1β-mediated tumorigenesis in human melanoma. Whereas NLRP3 regulation of caspase-1 activation requires the adaptor protein ASC, caspase-1 activation by another danger-signaling sensor...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhai, Zili, Liu, Weimin, Kaur, Manjinder, Luo, Yuchun, Domenico, Joanne, Samson, Jenny Mae, Shellman, Yiqun G, Norris, David A, Dinarello, Charles A, Spritz, Richard A, Fujita, Mayumi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501746/
https://ncbi.nlm.nih.gov/pubmed/28263976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.26
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