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Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β

Interleukin-1β (IL-1β) is a pleiotropic cytokine promoting inflammation, angiogenesis, and tissue remodeling as well as regulation of immune responses. Although IL-1β contributes to growth and metastatic spread in experimental and human cancers, the molecular mechanisms regulating the conversion of...

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Bibliografiske detaljer
Main Authors: Okamoto, Miyako, Liu, Weimin, Luo, Yuchun, Tanaka, Aki, Cai, Xiangna, Norris, David A., Dinarello, Charles A., Fujita, Mayumi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825443/
https://ncbi.nlm.nih.gov/pubmed/20038581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064907
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