Hepatitis C virus activates interleukin-1β via caspase-1-inflammasome complex

Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine involved in the pathogenesis of HCV, but the sensors and underlying mechanisms that facilitate HCV-induced IL-1β proteolytic activation and secretion remains unclear. In this study, we have identified a signalling pathway leading to IL-1β...

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Autores principales: Burdette, Dylan, Haskett, Adam, Presser, Lance, McRae, Steven, Iqbal, Jawed, Waris, Gulam
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for General Microbiology 2012
Materias:
Animal
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352344/
https://ncbi.nlm.nih.gov/pubmed/21994322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.034033-0
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