The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism

Hepatitis C virus (HCV) relies on host lipids and lipid droplets for replication and morphogenesis. The accumulation of lipid droplets in infected hepatocytes manifests as hepatosteatosis, a common pathology observed in chronic hepatitis C patients. One way by which HCV promotes the accumulation of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: McRae, Steven, Iqbal, Jawed, Sarkar-Dutta, Mehuli, Lane, Samantha, Nagaraj, Abhiram, Ali, Naushad, Waris, Gulam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751372/
https://ncbi.nlm.nih.gov/pubmed/26698881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.694059
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