The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism

Hepatitis C virus (HCV) relies on host lipids and lipid droplets for replication and morphogenesis. The accumulation of lipid droplets in infected hepatocytes manifests as hepatosteatosis, a common pathology observed in chronic hepatitis C patients. One way by which HCV promotes the accumulation of...

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Udgivet i:J Biol Chem
Main Authors: McRae, Steven, Iqbal, Jawed, Sarkar-Dutta, Mehuli, Lane, Samantha, Nagaraj, Abhiram, Ali, Naushad, Waris, Gulam
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751372/
https://ncbi.nlm.nih.gov/pubmed/26698881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.694059
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