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Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494

Several intracellular pathogens arrest the phagosome maturation in the host cells to avoid transport to lysosomes. In contrast, the Leishmania containing parasitophorous vacuole (PV) is shown to recruit lysosomal markers and thus Leishmania is postulated to be residing in the phagolysosomes in macro...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Verma, Jitender Kumar, Rastogi, Ruchir, Mukhopadhyay, Amitabha
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501680/
https://ncbi.nlm.nih.gov/pubmed/28650977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006459
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