Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis

Genomic studies have revealed significant branching heterogeneity in cancer. Studies of resistance to tyrosine kinase inhibitor therapy have not fully reflected this heterogeneity because resistance in individual patients has been ascribed to largely mutually exclusive on-target or off-target mechan...

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Bibliographic Details
Published in:Blood
Main Authors: Smith, Catherine C., Paguirigan, Amy, Jeschke, Grace R., Lin, Kimberly C., Massi, Evan, Tarver, Theodore, Chin, Chen-Shan, Asthana, Saurabh, Olshen, Adam, Travers, Kevin J., Wang, Susana, Levis, Mark J., Perl, Alexander E., Radich, Jerald P., Shah, Neil P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501146/
https://ncbi.nlm.nih.gov/pubmed/28490572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-711820
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