Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors

Umbilical cord blood (CB) is a convenient and broadly used source of hematopoietic stem cells (HSCs) for allogeneic stem cell transplantation. However, limiting numbers of HSCs remain a major constraint for its clinical application. Although one feasible option would be to expand HSCs to improve the...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Wojtowicz, Edyta E., Lechman, Eric R., Hermans, Karin G., Schoof, Erwin M., Wienholds, Erno, Isserlin, Ruth, van Veelen, Peter A., Broekhuis, Mathilde J.C., Janssen, George M.C., Trotman-Grant, Aaron, Dobson, Stephanie M., Krivdova, Gabriela, Elzinga, Jantje, Kennedy, James, Gan, Olga I., Sinha, Ankit, Ignatchenko, Vladimir, Kislinger, Thomas, Dethmers-Ausema, Bertien, Weersing, Ellen, Alemdehy, Mir Farshid, de Looper, Hans W.J., Bader, Gary D., Ritsema, Martha, Erkeland, Stefan J., Bystrykh, Leonid V., Dick, John E., de Haan, Gerald
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500905/
https://ncbi.nlm.nih.gov/pubmed/27424784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.06.008
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