MiR-125a enhances self-renewal, lifespan, and migration of murine hematopoietic stem and progenitor cell clones

Expansion of hematopoietic stem cells (HSCs) is a ‘holy grail’ of regenerative medicine, as successful stem cell transplantations depend on the number and quality of infused HSCs. Although many attempts have been pursued to either chemically or genetically increase HSC numbers, neither clonal analys...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Wojtowicz, Edyta Ewa, Broekhuis, Mathilde Johanna Christina, Weersing, Ellen, Dinitzen, Alexander, Verovskaya, Evgenia, Ausema, Albertina, Ritsema, Martha, Zwart, Erik, de Haan, Gerald, Bystrykh, Leonid V.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423273/
https://ncbi.nlm.nih.gov/pubmed/30886165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38503-z
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