MiR-125a enhances self-renewal, lifespan, and migration of murine hematopoietic stem and progenitor cell clones

Expansion of hematopoietic stem cells (HSCs) is a ‘holy grail’ of regenerative medicine, as successful stem cell transplantations depend on the number and quality of infused HSCs. Although many attempts have been pursued to either chemically or genetically increase HSC numbers, neither clonal analys...

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Pubblicato in:Sci Rep
Autori principali: Wojtowicz, Edyta Ewa, Broekhuis, Mathilde Johanna Christina, Weersing, Ellen, Dinitzen, Alexander, Verovskaya, Evgenia, Ausema, Albertina, Ritsema, Martha, Zwart, Erik, de Haan, Gerald, Bystrykh, Leonid V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423273/
https://ncbi.nlm.nih.gov/pubmed/30886165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38503-z
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